A recent study[1] published in Genetics in Medicine Open by researchers at Nemours Children’s Hospital in Delaware, has identified a new syndrome in infants born to mothers who were exposed to fentanyl during pregnancy. Multiple physical abnormalities, including small head size, slowed growth, and distinct facial features characterize this emerging syndrome. Some affected children also exhibit cleft palate, rocker bottom feet, and malformed genitalia.
Impact of Opioid Use During Pregnancy
The study highlights the severe impact of opioid use, particularly fentanyl, during pregnancy. Previous research has extensively documented the effects of opioid exposure on fetuses, which include preterm delivery, low birth weight, reduced head circumference, and neonatal abstinence syndrome. These infants are also at higher risk for sudden infant death and congenital malformations, such as heart defects and neural tube defects.
The findings from this study add to the growing concern that prenatal opioid exposure could lead to long-term physical and developmental challenges similar to those observed in fetal alcohol syndrome. While fentanyl’s role in causing congenital disabilities has been recognized, this study provides new evidence confirming those risks.
Implications and Recommendations for Opioid Use
The study’s findings underscore the urgent need for OB/GYNs to be vigilant in identifying opioid use among women of childbearing age. Early detection and appropriate treatment for opioid use disorder are crucial in preventing these severe outcomes. By addressing opioid use before or during pregnancy, healthcare providers can help reduce the risk of these newly identified and potentially life-altering syndromes in infants.
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[1] https://www.contemporaryobgyn.net/view/prenatal-fentanyl-exposure-and-a-novel-syndrome